Water → Ethyl 4-azidobutanoate

HRID 964290노트

반응식

HRID 964290 반응식
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[N-:10]=[N+:11]=[N-:12].[Na+].O>CO>[N:10]([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])=[N+:11]=[N-:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 76300Ethyl 4-bromobutyrate

생성물 1

HCID 12382175Ethyl 4-azidobutanoate수율 98.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of ethyl 4-bromobutyrate (10.0 g, 51.3 mmol), NaN3 (6.66 g, 102 mmol) and 25 ml of water in 75 ml of MeOH was refluxed for 3.5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water. After drying and evaporation of solvent, ethyl 4-azidobutyrate (7.94 g, 98.6%) was obtained as a colorless oil.

후처리

  1. customThe MeOH was removed in vacuo and residue
  2. customwas partitioned between CHCl3 (200 ml) and water (50 ml)
  3. customThe organic layer was separated
  4. washwashed with water
  5. customAfter drying
  6. customevaporation of solvent

출처 및 근거

ORD 기록
ord-4216cb94fc8f47f48f362fac784c7a19
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05767131

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