Imidazole → HCID 22097613, 화합물

HRID 964581노트

반응식

HRID 964581 반응식
[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 3832489Benzyl 4-bromobutanoate

생성물 1

HCID 22097613HCID 22097613, 화합물수율 33%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-bromobutyric acid benzyl ester (23.7 g), imidazole (8.1 g), potassium carbonate (14.0 g) and acetone (400 ml) was stirred under refluxing conditions for 6 hours. After the reaction mixture was cooled to room temperature, the insoluble solid was filtered off, the filtrate was concentrated. The residual oily substance was subjected to silica gel column chromatography and eluted with ethyl acetate-methanol (20:1, v/v) to yield 4-(1-imidazolyl)butyric acid benzyl ester (7.3 g, 33%) as an oily substance.

후처리

  1. filtrationthe insoluble solid was filtered off
  2. concentrationthe filtrate was concentrated
  3. washeluted with ethyl acetate-methanol (20:1

출처 및 근거

ORD 기록
ord-3ed45cadc4b34ceba705c957520c258a
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05770602

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