Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → 3-amino-N,N-dimethylbenzene-1-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | 3-Nitrobenzenesulfonyl chloride | HCID 8476 | — |
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-amino-N,N-dimethylbenzene-1-sulfonamide | HCID 235520 | — |
반응 단계
Following the procedure described in part E of Example 1 (R), (S)-α-[[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-4-methoxybenzeneacetic acid was condensed with 3-[(dimethylamino)sulfonyl]aniline to generate the title compound. The 3-[(dimethylamino)sulfonyl]aniline was prepared by sequential treatment of commercial 3-nitrobenzenesulfonyl chloride with Me2NH in CH2Cl2 containing (i-Pr)2NEt followed by reduction with SnCl2 in EtOAc at 20° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05770615 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-927dc624ac08435ba16a97ce88a8e884 |
| 출처 메모 | uspto-grants-1998_06 |