4-(Trifluoromethyl)phenol → {3-{[4-(Trifluoromethyl)phenoxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

반응식

Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[S:5][C:4]=1[C:18](OCC)=[O:19].[F:23][C:24]([F:33])([F:32])[C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=1>>[F:23][C:24]([F:32])([F:33])[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH2:2][C:3]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:15])[F:17])=[CH:10][CH:9]=3)[S:5][C:4]=2[CH2:18][OH:19])=[CH:27][CH:26]=1

참가 물질

반응물 2

HCID 678744-(Trifluoromethyl)phenol

HCID 21986402Ethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate

생성물 1

HCID 21986459{3-{[4-(Trifluoromethyl)phenoxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

실험 절차

Prepared from intermediate 43 and 4-(trifluoromethyl)phenol

출처 및 근거

ORD 기록: ord-b23a0f8e590a4f68ab5573dd18023026
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091237B2

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