Butylamine → n4-Butyl-6-chloropyrimidine-2,4-diamine
반응식
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([NH:14][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[C:6]([Cl:8])[N:7]=1참가 물질
4
실험 절차
10 g of 2-amino-4,6-dichloropyrimidine are suspended in 100 ml of ethanol. 11.15 g of butylamine are added. The reaction mixture is refluxed for 2 hours and then evaporated to dryness. The residue is taken up in 100 ml of water. After 1 hour's stirring the precipitate is filtered off on sintered glass and is then recrystallized from 80 ml of 6/4 water/acetonitrile. 8.75 g of 2-amino-4-butylamino-6-chloropyrimidine are obtained.
후처리
- temperatureThe reaction mixture is refluxed for 2 hours
- customevaporated to dryness
- filtrationis filtered off on sintered glass
- customis then recrystallized from 80 ml of 6/4 water/acetonitrile
출처 및 근거
- ORD 기록
- ord-eab0454af4b841da9a5e016277412805
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05772990
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