4-Methylbenzaldehyde → {2-[2-(4-Methylphenyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

반응식

[Br-].C[O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[O:8][C:7]=1[CH2:21][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=O.[CH3:41][C:42]1[CH:49]=[CH:48][C:45]([CH:46]=O)=[CH:44][CH:43]=1>>[CH3:41][C:42]1[CH:49]=[CH:48][C:45]([CH2:46][CH2:21][C:7]2[O:8][C:9]([C:11]3[CH:12]=[CH:13][C:14]([C:17]([F:19])([F:18])[F:20])=[CH:15][CH:16]=3)=[CH:10][C:6]=2[CH2:4][OH:3])=[CH:44][CH:43]=1

참가 물질

반응물 2

HCID 77254-Methylbenzaldehyde

HCID 86593915({3-(Methoxycarbonyl)-5-[4-(trifluoromethyl)phenyl]-2-furyl}methyl)(triphenyl)phosphonium bromide

생성물 1

HCID 21986437{2-[2-(4-Methylphenyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

실험 절차

prepare from intermediate 62 and 4-methylbenzaldehyde

출처 및 근거

ORD 기록: ord-23f9c05e875c4e10a0232c503746efde
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091237B2

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