N-Benzyl 2-(Carbobenzyloxyamino)-3-Methoxypropionamide → 2-amino-N-benzyl-3-methoxypropanamide
반응식
[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH:14]C(OCC1C=CC=CC=1)=O)[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH2:14])[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
3
실험 절차
To a solution of 12 (122.8 mg, 0.36 mmol) in methanol (2.0 mL) was added 10% Pd--C (11 mg) and the mixture stirred at room temperature in the presence of H2 gas for 75 min. Celite was added to the reaction mixture and the catalyst was removed by filtration. The clear filtrate was evaporated in vacuo to give pure 13 as a clear viscous oil (72 mg, 97%): Rf 0.30 (5% MeOH/CHCl3).
후처리
- additionCelite was added to the reaction mixture
- customthe catalyst was removed by filtration
- customThe clear filtrate was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-d3ef1ecaa8764943bd7ba0efad2cb582
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05773475
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