2-(2-Chloroethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxyethyl)-3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

반응식

[CH3:1][S:2][C:3]1([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].Cl[CH2:21][CH2:22][O:23]C1CCCCO1>>[OH:23][CH2:22][CH2:21][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([S:2][CH3:1])([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]1=[O:12]

참가 물질

반응물 2

HCID 2549512-(2-Chloroethoxy)tetrahydro-2H-pyran

HCID 190750183-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 190750041-(2-Hydroxyethyl)-3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

실험 절차

Prepared from 3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one and 2-(2-chloroethoxy)tetrahydro-2H-pyran as described in Example 1.

출처 및 근거

ORD 기록: ord-153e8cf776dd4ac1a534946fd8d433e1
출처 데이터셋: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05773448

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