Potassium Carbonate → 4-[2-(3-Fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-2-methyl-5-propyl-pyrimidine

HRID 965687노트

반응식

HRID 965687 반응식
Cl[C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[C:13]2[C:17]2[C:22]([F:23])=[CH:21][CH:20]=[CH:19][N:18]=2)[N:5]=[C:4]([CH3:24])[N:3]=1.C([O-])([O-])=O.[K+].[K+]>C(O)C.[Pd]>[F:23][C:22]1[C:17]([C:13]2[N:12]([CH2:11][C:6]3[C:7]([CH2:8][CH2:9][CH3:10])=[CH:2][N:3]=[C:4]([CH3:24])[N:5]=3)[CH:16]=[CH:15][N:14]=2)=[N:18][CH:19]=[CH:20][CH:21]=1

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 99977004-Chloro-6-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-2-methyl-5-propyl-pyrimidine

생성물 1

HCID 223131584-[2-(3-Fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-2-methyl-5-propyl-pyrimidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4-chloro-6-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-2-methyl-5-propyl-pyrimidine (55.3 mg, 0.16 mmol), K2CO3 (30 mg) and Pd—C (10%, 6 mg) in ethanol is stirred at room temperature under H2 (H2 balloon) over night. After filtration, the solvent is removed and the residue is purified by preparative TLC to give the title compound. 1H NMR (CDCl3) 8.34 (s, 1H), 8.31-8.33 (m, 1H), 7.50-7.55 (m, 1H), 7.23-7.28 (m, 2H), 7.10 (s, 1H), 5.73 (s, 2H), 2.54 (s, 3H), 2.48 (t, 2H), 1.44-1.53 (m, 2H), 0.89 (t, 3H).

후처리

  1. filtrationAfter filtration
  2. customthe solvent is removed
  3. customthe residue is purified by preparative TLC

출처 및 근거

ORD 기록
ord-e9dc5277bea043f58aabcb132b1727f5
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951864B2

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