Ethyl cyanoacetate → 6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

HRID 965783노트

반응식

HRID 965783 반응식
[OH:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([OH:11])=[CH:6][C:3]=1[CH:4]=O.[C:12]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])#[N:13]>CN(C=O)C.N1CCCCC1.C(O)(=O)C>[CH2:18]([O:17][C:15]([C:14]1[C:12](=[NH:13])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][C:7]([OH:11])=[C:8]([OH:10])[CH:9]=2)=[O:16])[CH3:19]

참가 물질

6

반응물 2

HCID 7764Ethyl cyanoacetateHCID 6433872,4,5-Trihydroxybenzaldehyde

생성물 1

HCID 1363776256,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

시약·촉매·용매 3

HCID 176Acetic Acid촉매HCID 8082Piperidine촉매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2,4,5-trihydroxybenzaldehyde (2.94 g) and ethyl cyanoacetate (1.62 g) in DMF (20 ml) were added 20 drops (Pasteur pipette) of piperidine and eight drops of acetic acid and the solution kept at 80° C. under nitrogen for two hours. The product was filtered and washed with DMF and ethyl ether. Yield: 2.00 g.

후처리

  1. filtrationThe product was filtered
  2. washwashed with DMF and ethyl ether

출처 및 근거

ORD 기록
ord-3c8480c2150a4cc39986f0d6baa4f641
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951870B2

반응 노트

불러오는 중…