1-Bromo-2-butanone → Methyl 5-amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylate

반응식

[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]([Cl:12])=[C:4]([NH2:13])[N:3]=1.Br[CH2:15][C:16](=O)[CH2:17][CH3:18]>>[NH2:13][C:4]1[N:3]2[CH:15]=[C:16]([CH2:17][CH3:18])[N:1]=[C:2]2[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[Cl:12]

참가 물질

반응물 2

HCID 131561-Bromo-2-butanone

HCID 12088100Methyl 2,6-Diamino-5-chloronicotinate

생성물 1

HCID 22236485Methyl 5-amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylate

실험 절차

The title compounds were prepared according to the procedure described in the step 4 in Example 2 from methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (Example 2, Step 3) and 1-bromo-2-butanone.

출처 및 근거

ORD 기록: ord-2530d866dbce4fc5a3362f2e7110e7a8
출처 데이터셋: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06951867B2

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