Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylbenzaldehyde → 2-(2-p-Tolyl-vinyl)-pyridine 1-oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylbenzaldehyde | HCID 7725 | — |
| 반응물 | 2-Methylpyridine 1-oxide | HCID 13602 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(2-p-Tolyl-vinyl)-pyridine 1-oxide | HCID 69592129 | 55% |
반응 단계
To a refluxing solution of 2-picoline-1-oxide (10.9 g, 100 mmol), potassium tert.-butanolate ( 11.2 g, 100 mmol) in butanol (100 ml) was added portion-wise p-tolualdehyde (12.0 g, 100 mmol). Reflux was maintained for 90 min. Then the mixture was cooled to rt, diluted with H2O (100 ml) and extracted with CH2Cl2. The combined organic phases were dried with MgSO4, concentrated and chromatographed (SiO2 with CH2Cl2/MeOH=95:5) to provide the title compound (11.6 g, 55%) as a yellow solid material. MS: m/e=211 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06951875B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-a495954aa2bd448ba35baf9716c9dcc7 |
| 출처 메모 | uspto-grants-2005_10 |