Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfate → 6-(2-p-Tolyl-vinyl)-pyridine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 2-(2-p-Tolyl-vinyl)-pyridine 1-oxide | HCID 69592129 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 6-(2-p-Tolyl-vinyl)-pyridine-2-carbonitrile | HCID 69592042 | — |
반응 단계
In a variation to the procedure referred to in example 1, 2-(2-p-tolyl-vinyl)-pyridine 1-oxide (9.8 g, 46 mmol) was reacted first with dimethylsulfate ( 5.8 g, 46 mmol) and then with NaCN (2.74 g, 56 mmol). After extraction and crystallization 6-(2-p-tolyl-vinyl)-pyridine-2-carbonitrile (5.8 g, 57%) was obtained as a yellow crystalline material. Mp. 137-138° C. (isopropanol), MS: m/e=220 (M+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06951875B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-4f80f94ca7fb497abb25fde0d2a3ffae |
| 출처 메모 | uspto-grants-2005_10 |