Potassium Hydroxide → 2-Bromo-6-ethyl-pyridine 1-oxide
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[N:3]=1.[OH-:10].[K+]>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[N+:3]=1[O-:10]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 2-bromo-6-ethyl-pyridine (15.4 g, 82.8 mmol) (S. G. Davies and M. R. Shipton, J. Chem. Soc., Perkin Trans. 1, 1991, 3, 501) in acetic acid (15 ml) peracetic acid (26 ml of a 39%) solution) was added maintaining T<50° C. After completed addition the mixture was stirred at 50° C. for 5 hr and then cooled to rt. Crushed ice (40 g) was added and the mixture was made basic (pH 12) using 40% KOH solution. After extraction with CHCl3 (6×60 ml) the combined organic phases were dried (Na2CO3) and evaporated to give 20.0 g (>100%) of the title compound, MS: m/e=201 (M+) as a yellow oil.
후처리
- additionaddition the mixture
- temperaturecooled to rt
- extractionAfter extraction with CHCl3 (6×60 ml) the combined organic phases
- dry with materialwere dried (Na2CO3)
- customevaporated
출처 및 근거
- ORD 기록
- ord-e533fd8a7f244e98a28135262bce7c85
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951875B2
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