HCID 22176515, 화합물 → 2-Bromo-6-methylpyridin-4-amine
반응식
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([CH2:11]C)[N+:3]=1[O-]>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:11])[N:3]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A solution of 2-bromo-6-ethyl-4-nitro-pyridine 1-oxide (15.9 g, 69 mmol) in acetic acid (310 ml) was treated with powdered iron (25.8 g, 462 mmol). The mixture was slowly heated to 100° C. and kept for 1 hr. Then the reaction mixture was cooled to rt and filtered. After evaporation of the solvent the residue was crystallized to yield the title compound as a beige material (88%). Mp. 75-77° C. (pentane), MS: m/e=200 (M+).
후처리
- temperatureThen the reaction mixture was cooled to rt
- filtrationfiltered
- customAfter evaporation of the solvent the residue
- customwas crystallized
출처 및 근거
- ORD 기록
- ord-1a3416907eb24c63b9b810d2fb40b780
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951875B2
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