1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-bromo-2-chloro-N-(2,2-diethoxyethyl)benzamide
반응식
[Cl:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:12]([O:14][CH:15]([O:18][CH2:19][CH3:20])[CH2:16][NH2:17])[CH3:13].CCN=C=NCCCN(C)C>C(Cl)Cl>[Br:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH:17][CH2:16][CH:15]([O:18][CH2:19][CH3:20])[O:14][CH2:12][CH3:13])=[O:6])=[C:2]([Cl:1])[CH:10]=1참가 물질
5
실험 절차
To a suspension of 2-chloro-4-bromobenzoic acid (10.0 g, 42.47 mmol) in CH2Cl2 (1000 mL) was added aminoacetaldehyde diethyl acetal (5.1 mL, 46.72 mmol) and WSC (9.77 g, 50.96 mmol) at room temperature, and stirred for 4 hours. The mixture was washed with water (100 mL), dried over MgSO4. Removal of the solvent, gave title compound (14.88 g, 100% yield).
후처리
- washThe mixture was washed with water (100 mL)
- dry with materialdried over MgSO4
- customRemoval of the solvent
출처 및 근거
- ORD 기록
- ord-95d82ffb88ad4c04a01350bdfeb2358f
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951876B2
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