Bromine → 2-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone

HRID 965972

반응식

HRID 965972 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([CH3:11])[CH:3]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][C:4]=1[CH3:11])=[O:10]

참가 물질

4

반응물 2

HCID 24408BromineHCID 701334-Hydroxy-2-methylacetophenone

생성물 1

HCID 178121702-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone수율 81%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a stirred solution of 4′-hydroxy-2′-methylacetophenone (4.5 g, 30.0 mmol) in dioxane (7 ml) was added a solution of bromine (4.87 g, 30.5 mmol) in dioxane (28 ml) dropwise at room temperature. After addition, the mixture was stirred at room temperature for 30 minutes. The volatile was evaporated in vacuo, and the residue was used for next reaction without further purification. (5.57 g, 81% yield).

후처리

  1. additionAfter addition
  2. customThe volatile was evaporated in vacuo
  3. customthe residue was used for next reaction without further purification

출처 및 근거

ORD 기록
ord-cf2ce567f7634731ae3011b5e30108e1
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951876B2

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