2-Acetylbutyrolactone → HCID 178432037, 화합물

HRID 965992노트

반응식

HRID 965992 반응식
Br.[NH2:2][C:3]1[NH:7][N:6]=[C:5]([CH3:8])[C:4]=1[Br:9].[C:10]([CH:13]1[CH2:18][CH2:17][O:16][C:14]1=[O:15])(=O)[CH3:11]>C(O)C>[Br:9][C:4]1[C:5]([CH3:8])=[N:6][N:7]2[C:14]([OH:15])=[C:13]([CH2:18][CH2:17][OH:16])[C:10]([CH3:11])=[N:2][C:3]=12

참가 물질

4

반응물 2

HCID 106012-AcetylbutyrolactoneHCID 178419529HCID 178419529, 화합물

생성물 1

HCID 178432037HCID 178432037, 화합물수율 31.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 5-amino-4-bromo-3-methylpyrazole hydrobromide (13 g, 51 mmol) and α-acetyl-γ-butyrolactone (6.8 g, 53 mmol) in ethanol (65 mL) was heated under reflux for nine hours. After cooling to room temperature, the resulting crystals were collected by filtration, to give the title compound (4.6 g) as white crystals.

후처리

  1. temperatureunder reflux for nine hours
  2. filtrationthe resulting crystals were collected by filtration

출처 및 근거

ORD 기록
ord-301fb18165de450c9d1f7329c9ad1eec
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951865B2

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