2-Acetylbutyrolactone → 3-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone

HRID 966024

반응식

HRID 966024 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([CH:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])(=O)[CH3:10]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH:5][C:9](=[C:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])[CH3:10]

참가 물질

4

반응물 2

HCID 106012-AcetylbutyrolactoneHCID 122713-Iodoaniline

생성물 1

HCID 695835373-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone수율 99.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3-iodoaniline (5.0 g, 23 mmol), α-acetyl-γ-butyrolactone (14.6 g, 0.11 mol) in ethanol (100 mL) was heated under reflux for seven days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.54 g) as white crystals.

후처리

  1. temperatureunder reflux for seven days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-5a95d79f963c47cfb60e1135f1379845
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951865B2

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