반응식
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]2[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:16](=[O:17])[C@:10]2([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:9]1)=[O:7])(C)(C)C.[CH2:31]([O:38][CH2:39][CH:40]([NH:44][C:45](=[O:57])[C:46]([NH:49][C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])([CH3:48])[CH3:47])C(O)=O)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.CCCP1(OP(CCC)(=O)OP(CCC)(=O)O1)=O>>[C:53]([O:52][C:50](=[O:51])[NH:49][C:46]([C:45](=[O:57])[NH:44][C@H:40]([CH2:39][O:38][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]2[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:20])([F:21])[F:22])[C:16](=[O:17])[C@:10]2([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:9]1)=[O:7])([CH3:48])[CH3:47])([CH3:54])([CH3:55])[CH3:56]참가 물질
4
반응물 3
생성물 1
실험 절차
reacting said 1,3-dioxo-8a(S)-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-hexahydro-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester with 3-benzyloxy-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-propionic acid in the presence of a tertiary amine and 1-propanephosphonic acid cyclic anhydride in a reaction inert solvent to form (1-(1(R)-benzyloxymethyl-2-(1,3-dioxo-8a(S)-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-hexahydro-imidazo[1,5-a]pyrazin-7-yl)-2-oxo-ethylcarbamoyl)-1-methyl-ethyl)-carbamic acid tert-butyl ester; and
출처 및 근거
- ORD 기록
- ord-57ba728da88f45cab5e0a30110063611
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06953791B2
연결된 노트
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