Ethanaminium, N,N,N-triethyl-, fluoride (1:1) → {3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol

HRID 9675

반응식

HRID 9675 반응식
C([Si](C(C)C)(C(C)C)[O:5][CH2:6][C:7]1[S:8][C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=2)=[CH:10][C:11]=1[CH3:12])(C)C.[F-].C([N+](CC)(CC)CC)C>O1CCCC1>[CH3:12][C:11]1[CH:10]=[C:9]([C:13]2[CH:14]=[CH:15][C:16]([O:19][C:20]([F:23])([F:21])[F:22])=[CH:17][CH:18]=2)[S:8][C:7]=1[CH2:6][OH:5]

참가 물질

4

반응물 2

HCID 69582Ethanaminium, N,N,N-triethyl-, fluoride (1:1)HCID 21986319Triisopropyl({3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methoxy)silane2회

생성물 1

HCID 21986356{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of triisopropyl({3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methoxy)silane (intermediate 117, 0.97 g) in tetrahydrofuran (30 ml) was treated with tetraethylammonium fluoride (0.392 g) and the reaction mixture stirred at ambient temperature for 1 hour. The solvent was evaporated and the residue purified by flash column chromatography using cyclohexane:ethyl acetate (2:1) as eluent to give the title compound.

후처리

  1. customThe solvent was evaporated
  2. customthe residue purified by flash column chromatography

출처 및 근거

ORD 기록
ord-edda2177b7974f31a0a1889e8a802dc0
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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