{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl)methanol
반응식
CC1C=C(C2C=CC(OC(F)(F)F)=CC=2)SC=1CO.[F:20][C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[C:24]([F:31])=[CH:23][C:22]=1[C:32]1[S:36][C:35]([CH2:37][O:38][Si](C(C)C)(C(C)C)C(C)C)=[C:34]([CH3:49])[CH:33]=1>>[F:20][C:21]1[CH:26]=[C:25]([C:27]([F:29])([F:28])[F:30])[C:24]([F:31])=[CH:23][C:22]=1[C:32]1[S:36][C:35]([CH2:37][OH:38])=[C:34]([CH3:49])[CH:33]=1참가 물질
3
실험 절차
The title compound was prepared using a method analogous to that used for the preparation of {3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 119).