Methanol → 1,4-dimethyl (2R)-2-hydroxybutanedioate

HRID 967614노트

반응식

HRID 967614 반응식
[C:1](Cl)(=O)C.[C:5]([OH:13])(=O)[C@@H:6]([CH2:8][C:9]([OH:11])=[O:10])[OH:7].[CH3:14][OH:15]>>[CH3:14][O:15][C:5](=[O:13])[C@H:6]([OH:7])[CH2:8][C:9]([O:11][CH3:1])=[O:10]

참가 물질

4

반응물 3

HCID 887MethanolHCID 6367Acetyl chlorideHCID 92824D-Malic acid

생성물 1

HCID 110626971,4-dimethyl (2R)-2-hydroxybutanedioate

실험 절차

To an ice cooled solution of methanol (250 mL) was added acetyl chloride (12.5 mL), and the solution was stirred for 1 hour at 0° C. (R)-Malic acid (20.0 g) was added, and the solution was stirred for 16 hours at room temperature. Solvent was removed by evaporation in vacuo leaving a quantitative yield of (R)-2-hydroxysuccinic acid dimethylester as an oil.

후처리

  1. additionwas added
  2. customSolvent was removed by evaporation in vacuo

출처 및 근거

ORD 기록
ord-e3f82f4225044ede884619191e8ae10a
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06953812B2

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