2,2-Dimethyl-propionic acid 1H-indazol-6-yl Ester → 2,2-Dimethyl-propionic Acid 1-(2-oxo-propyl)1H-indazol-6-yl Ester

HRID 967710

반응식

HRID 967710 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])[CH:8]=2)[CH:3]=[N:2]1>CN(C=O)C>[O:10]=[C:7]([CH3:8])[CH2:6][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:10][C:11](=[O:16])[C:12]([CH3:13])([CH3:15])[CH3:14])[CH:8]=2)[CH:3]=[N:2]1

참가 물질

3

반응물 1

HCID 697525662,2-Dimethyl-propionic acid 1H-indazol-6-yl Ester

생성물 1

HCID 697528362,2-Dimethyl-propionic Acid 1-(2-oxo-propyl)1H-indazol-6-yl Ester수율 137.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of the product of Step A (1.5 g, 6.9 mmol) in DMF (10 ml) was treated by the procedure described for Example 1, Step B to give an oil (1.3 g, 62%): 1H NMR (CDCl3) δ 8.09 (d, J=0.8 Hz, 1H), 7.99 (s, 1H), 7.90 (s, 1H), 7.58 (d, J=8.6 Hz, 1H), 7.01 and 6.96 (dd, J=2.0 and 8.6 Hz, 1H), 4.64 (s, 2H), 2.15 (s, 3H), 1.56 (s, 3H) 1.27 (s, 6H); MS(ES) m/z 275 (M+).

출처 및 근거

ORD 기록
ord-e163bc2972f34248a546e1fbd40c8182
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956036B1

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