1-Benzyl-4-(4-carboxyphenoxymethyl)piperidin-4-ol → 1-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol

HRID 967770노트

반응식

HRID 967770 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][Si](C=[N+]=[N-])(C)C.CCCCCC>CO>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=2)([OH:14])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 222912941-Benzyl-4-(4-carboxyphenoxymethyl)piperidin-4-olHCID 86587183Trimethylsilyldiazomethane hexane

생성물 1

HCID 222912651-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound (0.86 g) obtained in Step 4 was dissolved in methanol (10 mL) and to the solution was added a 2M trimethylsilyidiazomethan-hexane solution (1.3 mL). After completion of the reaction, the residue from which the solvent was removed under reduced pressure was purified by silica gel column chromatography (Chromatorex NH™) (eluent; ethyl acetate:hexane=1:19 to 1:9) to obtain the titled compound (0.8 g) as crystals.

후처리

  1. customAfter completion of the reaction
  2. customthe residue from which the solvent was removed under reduced pressure
  3. customwas purified by silica gel column chromatography (Chromatorex NH™) (eluent; ethyl acetate:hexane=1:19 to 1:9)

출처 및 근거

ORD 기록
ord-977f295bf3f34f6e9fe71dfc1a2dc284
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956046B2

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