1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol → 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

HRID 967774노트

반응식

HRID 967774 반응식
[ClH:1].CO.[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)#[N:5]>CO>[ClH:1].[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1)#[N:5]

참가 물질

4

반응물 2

HCID 102916131-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-olHCID 21893726Hydrochloride methanol

생성물 1

HCID 222912871-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

10% hydrochloric acid-methanol (0.2 mL) was added to a methanol solution (2 mL) of the compound (50 mg) obtained in Step 4 of Example 1. After the solvent was removed under reduced pressure, the residue obtained was crystallized from ether and collected by filtration to obtain the titled compound (48 mg) as crystals.

후처리

  1. customAfter the solvent was removed under reduced pressure
  2. customthe residue obtained
  3. customwas crystallized from ether
  4. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-aa80d6da31a1439097d934d520db2c33
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956046B2

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