4-(Bromoacetyl)benzonitrile → tert-butyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate

반응식

[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=1)(=[NH:4])[CH2:2][CH3:3].Br[CH2:23][C:24]([C:26]1[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[CH:28][CH:27]=1)=O>>[C:30]([C:29]1[CH:32]=[CH:33][C:26]([C:24]2[N:4]=[C:1]([CH2:2][CH3:3])[N:5]([C:6]3[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=3)[CH:23]=2)=[CH:27][CH:28]=1)#[N:31]

참가 물질

반응물 2

HCID 986544-(Bromoacetyl)benzonitrile

HCID 178458051HCID 178458051, 화합물

생성물 1

HCID 22291416tert-butyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate

실험 절차

The title compound was prepared according to the procedure described in step 4 of Example 26 from tert-butyl 2-[4-(propanimidoylamino)phenyl]ethylcarbamate and 4-(bromoacetyl)benzonitrile: MS (ESI) m/z 417 [M+H]+.

출처 및 근거

ORD 기록: ord-034fdd5f5e734a00b3ee8e8f06f89d9b
출처 데이터셋: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06956050B2

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