4-(Chloromethyl)benzoyl chloride → N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]4-chloromethylbenzamide

HRID 967906노트

반응식

HRID 967906 반응식
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[NH2:12][C:13]1[CH:14]=[C:15]([NH:20][C:21](=[O:31])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]([CH3:30])[CH3:29])[CH:23]=2)[CH:16]=[CH:17][C:18]=1[CH3:19]>>[CH3:30][N:28]([CH3:29])[C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[C:21]([NH:20][C:15]1[CH:16]=[CH:17][C:18]([CH3:19])=[C:13]([NH:12][C:7](=[O:8])[C:6]2[CH:10]=[CH:11][C:3]([CH2:2][Cl:1])=[CH:4][CH:5]=2)[CH:14]=1)=[O:31]

참가 물질

3

반응물 2

HCID 701364-(Chloromethyl)benzoyl chlorideHCID 22057981HCID 22057981, 화합물

생성물 1

HCID 22291036N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]4-chloromethylbenzamide

실험 절차

4-Chloromethylbenzoyl chloride was reacted with N-(3-amino-4-methylphenyl)-3-dimethylaminobenzamide using an analogous procedure to that described in Example 37 except that the reaction product was triturated under water rather than under 2N aqueous hydrochloric acid solution. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 2.19 (s, 3H), 2.95 (s, 6H), 4.28 (s, 2H), 6.9 (d, 1H), 7.21 (m, 3H), 7.29 (d, 1H), 7.58 (d, 3H), 7.8 (s, 1H), 7.96 (d, 2H), 9.9 (s, 1H), 10.08 (s, 1H); Mass Spectrum: M−H− 420.

후처리

  1. customwas triturated under water rather than under 2N aqueous hydrochloric acid solution

출처 및 근거

ORD 기록
ord-9760db3b90f34f1d898c8177ec1a2202
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956037B2

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