HCID 22291207, 화합물 → tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

HRID 967923노트

반응식

HRID 967923 반응식
C([N:8]1[CH2:23][CH2:22][CH2:21][C:9]21[CH2:13][N:12]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][CH2:10]2)C1C=CC=CC=1>CO.[Pd]>[CH2:13]1[C:9]2([CH2:21][CH2:22][CH2:23][NH:8]2)[CH2:10][CH2:11][N:12]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

참가 물질

4

반응물 1

HCID 22291207HCID 22291207, 화합물

생성물 1

HCID 22291199tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of t-butyl 6-benzyl-2,6-diazaspiro[4.4]nonane-2-carboxylate (1.70 g, 5.37 mmol) in methanol (30 mL) was mixed with 10% palladium on carbon (50 mg). The mixture was shaken under a hydrogen atmosphere (50 psi) in a Parr hydrogenation apparatus for 8 h and filtered through Celite. The filtrate was concentrated by rotary evaporation and high vacuum treatment, leaving 1.26 g of viscous, light brown oil (>100%), which was of sufficient purity to be used in the subsequent reaction.

후처리

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation and high vacuum treatment

출처 및 근거

ORD 기록
ord-6ee79e1228bf4f389cf742d3eff3adde
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956042B2

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