Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N,N,2-Trimethylaniline | HCID 11869 | — |
| 반응물 | 2-Chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid | HCID 24806661 | — |
| 촉매 | Copper | HCID 23978 | — |
| 생성물 | 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid | HCID 24806259 | — |
반응 단계
The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid and trimethylaniline in the presence of potassium carbonate and copper in DMF. The desired product was isolated by silica gel column chromatography using 5% methanol in chloroform as solvent to give a tan solid, mp. 130-135° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06956047B1 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-70940a9dab06419bb1d0f36cd76ad076 |
| 출처 메모 | uspto-grants-2005_10 |