Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | [2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea | HCID 22015747 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine | HCID 22015735 | — |
반응 단계
To a solution of 1 [2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (XI) in acetic acid is added hydrobromic acid, and stirring continued for about 30 min at 80° C. DMSO is then added dropwise and the reaction mixture stirred for a further 30 min at 80° C. The product (XII) 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine is isolated by conventional means.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07304058B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-58071eab15a4470e83f4aaa19074f653 |
| 출처 메모 | uspto-grants-2007_12 |