4-Tert-Butylaniline →

HRID 968578노트

반응식

HRID 968578 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:22]([C:26]1[CH:32]=[CH:31][C:29](N)=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>CC(O)C>[C:22]([C:26]1[CH:32]=[CH:31][C:29]([ClH:1][C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]4[C:17]([C:18]([F:20])([F:19])[F:21])=[CH:16][CH:15]=[CH:14][N:13]=4)=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]

참가 물질

3

반응물 2

HCID 698614-Tert-ButylanilineHCID 220303844-Chloro-7-[3-(trifluoromethyl)-2-pyridinyl]quinazoline

생성물 0

아직 생성물 데이터가 없습니다.

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Stir 4-chloro-7-(3-trifluoromethyl-pyridin-2-yl)-quinazoline (0.16 mmol) and 4-tert-butyl-aniline (0.32 mmol) in IPA (4 mL) at 80° C. for 6 hours. Cool the mixture and collect the precipitate to obtain (4-tert-Butyl-phenyl)-[7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-yl] hydrochloride. Mass spec. 422.2.

후처리

  1. temperatureCool the mixture
  2. customcollect the precipitate

출처 및 근거

ORD 기록
ord-15f4cd1d245940d5b3c430f4b90729b2
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304059B2

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