Oxalyl chloride → 1-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride

HRID 968637노트

반응식

HRID 968637 반응식
[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([OH:21])=O)=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:25])=O>C1COCC1>[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([Cl:25])=[O:21])=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 686950531-(Cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid

생성물 1

HCID 859058491-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride수율 100.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-(cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid (2.5 g, 8.8 mmol) in THF (30 ml) was added oxalyl chloride (4.5 g, 35.3 mmol), dropwise with stirring. The mixture was stirred at room temperature for 18 h. The volatile components were evaporated under reduced pressure to afford 1-(cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride (2.7 g) as a crystalline solid.

후처리

  1. stirringThe mixture was stirred at room temperature for 18 h
  2. customThe volatile components were evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-af31ea58d986444ca2e570dd23ae8857
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304064B2

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