Pyridine → HCID 178430970, 화합물
반응식
[CH3:1][C:2]1[C:7]2[NH:8][CH:9]=[N:10][C:6]=2[C:5]([C:11](O)=[O:12])=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15].S(N)([NH2:20])(=O)=O.N1C=CC=CC=1>O>[CH3:1][C:2]1[C:7]2[NH:8][CH:9]=[N:10][C:6]=2[C:5]([C:11]([NH2:20])=[O:12])=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15]참가 물질
5
실험 절차
A mixture of 7-Methyl-6-nitro-1H-benzimidazole-4-carboxylic Acid (23) (0.692 g, 3.12 mmol), sulfamide (0.600 g, 6.26 mmol), and pyridine (8 mL) is heated at reflux for about 16 hours. The resulting heterogeneous reaction mixture is cooled to ambient temperature, diluted with water (10 mL) and cooled to 0° C. for 1 hour. The solids that form are filtered, washed with water (10 mL) and methanol (10 mL), and dried to obtain 7-Methyl-6-nitro-1H-benzimidazole-4-carboxamide (25) as a cream colored solid (0.586 g, 85% yield).
후처리
- temperatureis heated
- temperatureat reflux for about 16 hours
- temperaturecooled to 0° C. for 1 hour
- filtrationThe solids that form are filtered
- washwashed with water (10 mL) and methanol (10 mL)
- customdried
출처 및 근거
- ORD 기록
- ord-133e330d35fb4bce9aa6ed0269430265
- 출처 데이터셋
- uspto-grants-2007_12
- 특허 번호
- US07304084B2
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