1-(4-Methoxyphenyl)piperazine → {2-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

HRID 9688

반응식

HRID 9688 반응식
Br[CH2:2][C:3]1[O:4][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:6][C:7]=1[C:8]([O:10]C)=O.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([N:30]2[CH2:35][CH2:34][N:33]([CH2:2][C:3]3[O:4][C:5]([C:12]4[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=4)=[CH:6][C:7]=3[CH2:8][OH:10])[CH2:32][CH2:31]2)=[CH:28][CH:29]=1

참가 물질

3

반응물 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 21986318Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate2회

생성물 1

HCID 21986539{2-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

실험 절차

The title compound was prepared using methyl 2-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]-3-furoate (intermediate 44) and 1-(4-methoxyphenyl)piperazine.

출처 및 근거

ORD 기록
ord-b4b250cb2381419385197056ebaf170b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

연결된 노트

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