HCID 69459677, 화합물 → HCID 69459918, 화합물

HRID 969465노트

반응식

HRID 969465 반응식
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:35])[CH2:21][NH:22][C:23]([CH3:34])([CH3:33])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[F:32])=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)C1C=CC=CC=1>CO.[Pd]>[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[CH2:24][C:23]([NH:22][CH2:21][CH:20]([C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[C:18]2[C:13]=1[CH2:14][CH2:15][C:16](=[O:19])[NH:17]2)[OH:35])([CH3:33])[CH3:34]

참가 물질

4

반응물 1

HCID 69459677HCID 69459677, 화합물

생성물 1

HCID 69459918HCID 69459918, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 220 mg (0.5 mmol) 8-benzyloxy-5-{2-[2-(2,4-difluoro-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-1H-quinolin-2-one in 10 mL methanol is hydrogenated in the presence of palladium on charcoal at ambient temperature and normal pressure. Then the catalyst is separated off, the filtrate is evaporated down and the residue is chromatographed (reverse phase; water/acetonitrile gradient).

후처리

  1. customThen the catalyst is separated off
  2. customthe filtrate is evaporated down
  3. customthe residue is chromatographed (reverse phase; water/acetonitrile gradient)

출처 및 근거

ORD 기록
ord-eefb1c3489244838afd841f0be854723
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07307076B2

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