Sulfamide → 4-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide

HRID 969548노트

반응식

HRID 969548 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7]1.[S:22](N)([NH2:25])(=[O:24])=[O:23]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH:12]2[CH2:13][CH2:14][N:15]([S:22]([NH2:25])(=[O:24])=[O:23])[CH2:16][CH2:17]2)[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 82267SulfamideHCID 223974344-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine

생성물 1

HCID 231027624-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide수율 80.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-(3,4-Dichlorophenoxy)-1,4′-bipiperidine (5 g, 0.0152 mol) and sulfamide (1.45 g, 0.0152 mol) were stirred together in dioxan (150 ml) at reflux for 24 hours. The resulting mixture was cooled to ambient temperature, evaporated to dryness and the residue was triturated with ether to give the title compound as a tan solid (5 g; MS APCI 409/411 (M+H)).

후처리

  1. temperatureat reflux for 24 hours
  2. customevaporated to dryness
  3. customthe residue was triturated with ether

출처 및 근거

ORD 기록
ord-d4eb8159bf6f4990b3a63ba470156b55
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07307090B2

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