{5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl)methanol → Ethyl[4-({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

HRID 9696

반응식

HRID 9696 반응식
C(OC(=O)COC1C=CC(SCC2C=C(C3C=CC(C(F)(F)F)=CC=3)OC=2)=CC=1C)C.[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][C:39]=1[CH3:45])[CH3:33].[F:47][C:48]1[CH:53]=[C:52]([C:54]([F:57])([F:56])[F:55])[C:51]([F:58])=[CH:50][C:49]=1[C:59]1[S:63][C:62]([CH2:64]O)=[C:61]([CH3:66])[CH:60]=1>>[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([O:44][CH2:64][C:62]2[S:63][C:59]([C:49]3[CH:50]=[C:51]([F:58])[C:52]([C:54]([F:55])([F:57])[F:56])=[CH:53][C:48]=3[F:47])=[CH:60][C:61]=2[CH3:66])=[CH:40][C:39]=1[CH3:45])[CH3:33]

참가 물질

4

반응물 3

HCID 21986329{5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl)methanol2회HCID 21986458Ethyl (4-hydroxy-2-methylphenoxy)acetate2회HCID 21986477Ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate

생성물 1

HCID 21986311Ethyl[4-({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

실험 절차

The title compound was prepared by a method analogous to that used for the preparation of ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate (example 1) using ethyl(4-hydroxy-2-methylphenoxy)acetate (intermediate 7) and {5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol (intermediate 120).

출처 및 근거

ORD 기록
ord-ab08d73f10fa4a0ea110a92bbee126a5
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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