Cyclopentylamine → HCID 11219722, 화합물

HRID 969742노트

반응식

HRID 969742 반응식
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Cl:14][C:15]1[C:20]([CH:21]([CH3:23])[CH3:22])=[C:19](Cl)[N:18]2[N:25]=[CH:26][N:27]=[C:17]2[N:16]=1>C(Cl)Cl>[Cl:14][C:15]1[C:20]([CH:21]([CH3:22])[CH3:23])=[C:19]([NH:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[N:18]2[N:25]=[CH:26][N:27]=[C:17]2[N:16]=1

참가 물질

5

반응물 3

HCID 2906CyclopentylamineHCID 8471TriethylamineHCID 11345254[1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-dichloro-6-(1-methylethyl)-

생성물 1

HCID 11219722HCID 11219722, 화합물수율 76%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

With stirring, a mixture of 0.13 g (1.5 mmol) of cyclopentylamine and 0.15 g (1.5 mmol) of triethylamine in 10 ml of methylene chloride was added to a mixture of 0.34 g (1.5 mmol) of 5,7-dichloro-6-isopropyl-[1,2,4]-triazolo-[1,5-α]-pyrimidine (cf. Ex. 2) in 20 ml of methylene chloride. The reaction mixture was stirred at room temperature for 16 h and then washed with 5% strength hydrochloric acid. The organic phase was separated off, dried over sodium sulfate and filtered. The filtrate was freed from the solvent and the residue was purified chromatographically. This gave 0.32 g (1.14 mmol) of the title compound (melting point 139° C.).

후처리

  1. stirringThe reaction mixture was stirred at room temperature for 16 h
  2. washwashed with 5% strength hydrochloric acid
  3. customThe organic phase was separated off
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customthe residue was purified chromatographically

출처 및 근거

ORD 기록
ord-123f145a17f94a23b7aadd091ac54852
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07307172B2

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