Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate | HCID 68454443 | — |
| 생성물 | 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid | HCID 68456500 | 82% |
반응 단계
5-Chloro-2-phenylbenzoxazole-7-carboxylic acid was prepared from methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate via lithium hydroxide mediated hydrolysis as described in Step B of Example 14. This material was obtained as a white solid in 82% yield. 1H NMR (300 MHz, DMSO-d6) δ 13.84 (br s, 1H), 8.22-8.19 (m, 3H), 7.85 (d, J=2.1 Hz, 1H), 7.70-7.63 (m, 3H), 4.07 (s, 3H); MS (ESI) m/z 274 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07307094B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-c914d5351e1745a3a50e67d9fb59b9b7 |
| 출처 메모 | uspto-grants-2007_12 |