Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → Methyl 2-benzylideneaminohexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Methyl norleucinate--hydrogen chloride (1/1) | HCID 14039064 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 2-benzylideneaminohexanoate | HCID 23074255 | 100% |
반응 단계
To a suspension of 7.79 g of methyl 2-aminohexanoate hydrochloride in 70 ml of dichloromethane were added 8.67 g of triethylamine (manufactured by WAKO PURE CHEMICAL INDUSTRIES LTD.), 7.74 g of anhydrous magnesium sulfate, and 4.55 g of benzaldehyde and the resultant was stirred overnight at room temperature. The reaction suspension was then filtered and the filtrate was concentrated. 280 ml of ether was added to the residue and the resultant suspension was filtered and the filtrate was concentrated. Again, 280 ml of ether was added to the residue and filtration and concentration were similarly repeated to obtain 10.0 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07312208B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-332311d18c5f4149a4c880390161ac35 |
| 출처 메모 | uspto-grants-2007_12 |