Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonic Acid → N-Desmethyl imatinib mesylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Cgp-74588 | HCID 9869737 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Desmethyl imatinib mesylate | HCID 10188302 | — |
반응 단계
4.8 g (10 mmol) of N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-piperazin-1-ylmethyl-benzamide are dissolved in 20 ml of ethanol under heating and 0.99 g of methanesulfonic acid are added. After addition of ethyl acetate the product cristallizes. Drying at 50 mbar and 60° C. yields N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-piperazin-1-ylmethyl-benzamide methanesulfonate; Rf=0.17 (methylene chloride:ethyl acetate:methanol:conc. aqueous ammonium hydroxide solution=60:10:30:2); tR (HPLC)2) 14.6 min; m.p. 242-245° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07312216B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-08b49c26df48452d8d881cedddbfd239 |
| 출처 메모 | uspto-grants-2007_12 |