HCID 21054729, 화합물 → 1-Boc-4-aMino-4-trifluoroMethylpiperidine

HRID 970374노트

반응식

HRID 970374 반응식
C(OC([NH:11][C:12]1([C:25]([F:28])([F:27])[F:26])[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]1)=O)C1C=CC=CC=1>[Pd].CCO>[NH2:11][C:12]1([C:25]([F:28])([F:26])[F:27])[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[CH2:16][CH2:17]1

참가 물질

4

반응물 1

HCID 21054729HCID 21054729, 화합물

생성물 1

HCID 210547281-Boc-4-aMino-4-trifluoroMethylpiperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

10% Palladium on carbon (a catalytic amount) is added carefully to a solution of 4-(benzyloxycarbonyl)amino-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)piperidine (3d) (1 equiv.) in EtOH, and the mixture is shaken under H2 (50 psi) on a Parr apparatus. When the reaction is complete, the solution is filtered through a pad of celite®, and the filter pad is washed with EtOH. The filtrate is concentrated to yield the title compound.

후처리

  1. filtrationthe solution is filtered through a pad of celite®
  2. washthe filter pad is washed with EtOH
  3. concentrationThe filtrate is concentrated

출처 및 근거

ORD 기록
ord-bc4b36888cab4c0e86042163707bc827
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312212B2

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