Trifluoroacetic acid methylene chloride → HCID 68564037, 화합물

HRID 970376노트

반응식

HRID 970376 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([NH:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]3[S:28][CH2:27][C:26](=[O:29])[NH:25][C:24]=3[CH:30]=2)([C:14]([F:17])([F:16])[F:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:16][C:14]([F:15])([F:17])[C:11]1([NH:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]3[S:28][CH2:27][C:26](=[O:29])[NH:25][C:24]=3[CH:30]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

3

반응물 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 68565409HCID 68565409, 화합물

생성물 1

HCID 68564037HCID 68564037, 화합물

실험 절차

A solution of 6-[{1-(tert-butoxycarbonyl)-4-(trifluoromethyl)piperidin-4-ylamino}methyl]-4H-benzo[1,4]thiazin-3-one (3f) in 1:1 TFA/CH2Cl2 is stirred at room temperature until the starting material is consumed, then is concentrated to dryness in vacuo. The residue is partitioned between dilute NaOH and CH2Cl2, and the layers are separated. The aqueous layer is extracted with CH2Cl2, and the combined organic extracts are dried (Na2SO4) and concentrated in vacuo to afford the title compound.

후처리

  1. customis consumed
  2. concentrationis concentrated to dryness in vacuo
  3. customThe residue is partitioned between dilute NaOH and CH2Cl2
  4. customthe layers are separated
  5. extractionThe aqueous layer is extracted with CH2Cl2
  6. dry with materialthe combined organic extracts are dried (Na2SO4)
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2b8063bc6a994faea6b124db82654275
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312212B2

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