Chlorosuccinimide → Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate

HRID 970381노트

반응식

HRID 970381 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[Br:12].[Cl:13]N1C(=O)CCC1=O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([Cl:13])=[CH:4][C:3]=1[Br:12]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 10704661Methyl 6-amino-5-bromopicolinate

생성물 1

HCID 21873807Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate수율 95.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of methyl 6-amino-5-bromopyridine-2-carboxylate (20.04 g) in acetic acid (900 mL) was added N-chlorosuccinimide (13.96 g) and the resultant solution was heated to 120° C. for 1 hour. The solution was then evaporated and treated with excess aqueous sodium bicarbonate and extracted with dichloromethane. The organic fraction was dried and evaporated to give the product (21.98 g).

후처리

  1. customThe solution was then evaporated
  2. additiontreated with excess aqueous sodium bicarbonate
  3. extractionextracted with dichloromethane
  4. customThe organic fraction was dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-843bb1eecd8a453a8afee779bc9d9cff
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312212B2

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