HCID 23400263, 화합물 → HCID 68563556, 화합물

HRID 970387

반응식

HRID 970387 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]1[F:18])=O)C1C=CC=CC=1.[CH3:19][O:20][C:21]1[N:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[N:27]=[CH:26][CH:25]=[C:24]2[C@@H:31]1[CH2:33][O:32]1>>[NH2:11][CH:12]1[CH2:17][CH2:16][N:15]([CH2:33][C@@H:31]([C:24]2[C:23]3[C:28](=[CH:29][CH:30]=[C:21]([O:20][CH3:19])[N:22]=3)[N:27]=[CH:26][CH:25]=2)[OH:32])[CH2:14][CH:13]1[F:18]

참가 물질

3

반응물 2

HCID 23400263HCID 23400263, 화합물HCID 68566554benzyl N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamate

생성물 1

HCID 68563556HCID 68563556, 화합물

실험 절차

This was prepared from cis-4-benzyloxycarbonylamino-3-fluoropiperidine Enantiomer 2 (7a) and (R)-2-(6-methoxy-[1,5]-naphthyridin-4-yl)oxirane (20d) (100% ee) by the method of Example (20e).

출처 및 근거

ORD 기록
ord-b0bd71364f7744d992bdecbfa14b9a04
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312212B2

연결된 노트

불러오는 중…