HCID 23509661, 화합물 → 4-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

HRID 970404노트

반응식

HRID 970404 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][N:18](C(OCC4C=CC=CC=4)=O)[CH2:17]3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][NH:18][CH2:17]3)[CH2:11][CH2:10]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 23509661HCID 23509661, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 541749794-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirring solution of 3-[4-(4-flourophenylmethyl)piperidinomethyl]-N-(benzyloxycarbonyl)-pyrrolidine (600 mg, 1.47 mmol) and 5% palladium on carbon (60 mg, Aldrich) in MeOH (50 mL) was added 50 psi of hydrogen. The reaction was stirred for 14 h. The reaction was filtered and the filtrate was conc. in vacuo to a colorless oil. The oil can be used without further purification. MS (ESI) 277 (M+H).

후처리

  1. filtrationThe reaction was filtered
  2. customThe oil can be used without further purification

출처 및 근거

ORD 기록
ord-f8229e0edba541a8a7dd0fb2db3cc1e7
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312222B2

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