Thiophosgene → N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

HRID 970455

반응식

HRID 970455 반응식
[CH2:1]([NH2:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:12](Cl)([Cl:14])=[S:13]>ClCCl>[Cl-:14].[O:7]1[C:8]2[CH:9]=[CH:10][C:2]([CH2:1][NH:11][CH:12]=[S:13])=[CH:3][C:4]=2[O:5][CH2:6]1

참가 물질

4

반응물 2

HCID 10040ThiophosgeneHCID 75799Benzo-1,3-dioxole-5-methylamine

생성물 1

HCID 86601006N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of piperonylamine (0.1 mL, 0.77 mmol) in dichloromethane (20 mL) was slowly added thiophosgene (0.06 mL, 0.83 mmol) under cooling with an ice bath. After the reaction mixture was stirred for four hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum; and the product was used immediately for the next reaction.

후처리

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customand the product was used immediately for the next reaction

출처 및 근거

ORD 기록
ord-3b54fc26840d4e7ca015598d642ccb6a
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312226B2

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