Sulfadiazine → N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

HRID 970456

반응식

HRID 970456 반응식
[CH:1]1[CH:2]=[N:3][C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[N:5][CH:6]=1.[C:18](Cl)([Cl:20])=[S:19].C(N(CC)CC)C>ClCCl>[Cl-:20].[N:3]1[CH:2]=[CH:1][CH:6]=[N:5][C:4]=1[NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][CH:18]=[S:19])=[CH:13][CH:12]=1)(=[O:10])=[O:9]

참가 물질

5

반응물 3

HCID 5215SulfadiazineHCID 8471TriethylamineHCID 10040Thiophosgene

생성물 1

HCID 86601004N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of sulfadiazine (192 mg, 0.77 mmol) in dichloromethane (20 mL) were slowly added thiophosgene (0.06 mL, 0.83 mmol) and triethylamine (0.05 mL, 0.32 mmol) under cooling with an ice bath. After the reaction mixture was stirred for five hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum. The product was used immediately for the next reaction.

후처리

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customThe product was used immediately for the next reaction

출처 및 근거

ORD 기록
ord-b37488ecc727401f901f94bb23d8c7ce
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312226B2

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