1-Methyl-7-nitro-1,2,3,4-tetrahydroquinoline → 1-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

HRID 970648노트

반응식

HRID 970648 반응식
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-])=O)[CH:10]=2)[CH2:5][CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:12])[CH:10]=2)[CH2:5][CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 114809551-Methyl-7-nitro-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 112174211-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of the 1-methyl-7-nitro-1,2,3,4-tetrahydroquinoline (4.0 g, 20.81 mMol), Pd/C (2 g) in methanol (100 mL) was hydrogenated at 10 PSI for 2 hours. The catalyst was filtered off, and the filtrate was concentrated under vacuum to give the crude product which was used as such without further purification.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-84e481538b424c1098fee51d75ef8136
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312233B2

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